Although no other current test is more reliable for determining the activity of PTB than culture growth of bacilli, some biochemical parameters that reflect the inflammation present in patients with this condition may provide guidance at the diagnostic stage. The only definitive diagnostic method known for pulmonary TB (PTB) is the growth of Mtb bacilli from pulmonary material (sputum or bronchoscopic lavage fluid). Delayed diagnosis and treatment are also important public health issues.
According to a World Health Organization report, TB caused the death of 1,4 million people worldwide in 2010. Tuberculosis (TB) is a common infectious disease caused by Mycobacterium tuberculosis (Mtb), and it remains an important public health problem despite developments in its diagnosis and treatment. The use of MPV as an inflammation marker and a negative acute-phase reactant in PTB does not seem to be reliable. The MPV does not reflect the severity of the disease. The MPV was lower in patients with PTB than in healthy controls, however, the difference was limited. In the PTB group, CRP levels (r = 0.26, p = 0.003) and ESR (r = 0.39, p = 0.003), but not MPV (p = 0.80), were significantly correlated with the radiologic extent of the disease. The blood platelet count, CRP level, and ESR were significantly higher in the active PTB group than in the control group (p < 0.0001). In the PTB group, the relationships between the radiological extent of disease and the MPV and other inflammation markers were investigated. Whole blood counts, CRP level, and ESR were compared between the two groups. This study included 82 patients with active PTB and 95 healthy subjects (control group). In addition, its relationships with other inflammatory markers such as C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) as well as with the radiological extent of disease were examined. This prospective study aims to show the usability of MPV as an inflammation marker in patients with active pulmonary tuberculosis (PTB) by comparison with healthy controls.
It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases.
The mean platelet volume (MPV) reflects the size of platelets.
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